Thermo Fisher Scientific AMPD1 Polyclonal Antibody
Rabbit polyclonal antibody targeting AMPD1 protein for WB and IHC applications. Recognizes synthetic peptide immunogen of AMPDA1. Supplied as liquid, unconjugated form at 0.5 mg/mL concentration. Suitable for research use in adenosine metabolism and mu...
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- PA523173
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (506 MFSSKSPKPQEWTLEKN 522) of AMPDA1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2540699 |
Target Information
AMP deaminase (AMPD) is an allosteric enzyme involved in the regulation of adenosine metabolism. It catalyzes the conversion of AMP to IMP, releasing ammonia, and plays a central role in purine nucleotide biosynthesis.
There are three functional isoforms of AMPD. AMPD1 (E.C. No 3.5.4.6.) is the skeletal muscle-specific isoform located in type II muscle fibers, neuromuscular junctions, and capillaries.
AMPD1 acts as a sensor of the cell’s changing energy requirements. Deficiency in AMPD1 leads to irregular muscle metabolism due to reduced ATP degradation, phosphocreatine hydrolysis, and lactic acid accumulation. Mutated AMPD1 expression has been associated with neuromuscular disorders, exercise-induced skeletal muscle myopathies, and congestive heart failure related to coronary artery disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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