Thermo Fisher Scientific c-MAF Polyclonal Antibody
다양한 종에서 반응하는 c-MAF 폴리클로날 항체로 Western blot, IHC, ICC/IF, Flow cytometry에 사용 가능. 항원 친화 크로마토그래피로 정제된 고순도 항체. 장기 보관 시 -20°C에서 안정적이며 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:500 | View 1 publication |
| Flow Cytometry (Flow) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 75–110 of human c-MAF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540705 |
Target Information
c-MAF is the cellular counterpart of oncogenic v-maf, belonging to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain mediates interaction with LRPICD. Two forms of human c-maf mRNA exist: c-maf-long and c-maf-short. It was identified in the genome of the acute transforming avian retrovirus AS42.
c-MAF targets include IL-4 in Th2 cells, crystalline genes in lens fiber cells, insulin gene in islet, p53, and L7, exerting transcriptional roles through binding to the Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis and acts as a transcription factor for IL-10 expression in LPS-activated macrophages. Chromosomal aberrations involving maf occur in some forms of multiple myeloma. Expression is noted in myeloma cell lines and resting monocytes/macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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