Thermo Fisher Scientific TLR7 Polyclonal Antibody
TLR7 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, Flow cytometry 등에 사용 가능. 인간 및 비인간 영장류 반응성. Protein G로 정제된 액상 항체이며, 1 mg/mL 농도로 제공. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Flow Cytometry (Flow) | 1–2 µg/million cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate, Rhesus monkey |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A portion of amino acids 900–950 of human TLR7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2540700 |
Target Information
TLR7 is a highly conserved membrane protein of the Toll-like receptor (TLR) family, containing 27 leucine-rich repeats (LRR) and a TIR domain. It plays a key role in pathogen recognition and activation of innate immunity. TLR7 is activated by single-stranded RNA viruses such as influenza and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and is closely related to TLR8. Through MyD88 and TRAF6 pathways, TLR7 activation leads to NF-κB activation, cytokine secretion, and inflammatory responses. It recognizes pathogen-associated molecular patterns (PAMPs) to mediate cytokine production essential for effective immunity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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