Thermo Fisher Scientific TCR alpha/beta Monoclonal Antibody (IP26), Biotin

Applications

• Flow Cytometry (Flow): Tested dilution 2–3 µg/mL

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody recognizes a monomorphic extracellular determinant of TCR alpha/beta, the dominant subtype of T cell receptor expressed in human peripheral blood.

Target Information

The T cell antigen receptor (TCR) consists of a ligand-specific alpha/beta heterodimer associated with invariant CD3 gamma/delta/eta and zeta subunits, required for surface expression. Activation through TCR induces differentiation, proliferation, and cytokine production. Most T cells in blood and lymphoid organs express TCR alpha/beta, while gamma/delta T cells are mainly in epithelial tissues. Proper assembly of TCR-CD3 complex is essential for surface expression. TCR recognition of self-peptides is linked to autoimmune diseases and tumor-associated mutations. Superantigen engagement can lead to toxic shock syndrome. Autoantibodies to V beta segments have been found in RA and SLE patients, potentially modulating inflammatory responses. Alpha-beta T cells are primarily CD4+ or CD8+ (SP), while DN T cells (CD4-/CD8-) are increased in some immune disorders. Gamma-delta T cells exhibit limited diversity and distinct antigen recognition, with subsets showing antitumor and immunoregulatory activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.