Thermo Fisher Scientific SHIP1 Monoclonal Antibody (SHIP-02)
SHIP1 단백질을 인식하는 마우스 단클론 항체로, Western blot, ICC/IF, 유세포분석에 적합합니다. 인간 및 마우스 시료에 반응하며, Protein A로 정제된 액상 형태입니다. PBS(pH 7.4)에 15mM sodium azide가 포함되어 있으며 4°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 2–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SHIP-02 |
| Immunogen | Peptide corresponding to a sequence within the N-terminal domain of Human SHIP-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154124 |
Product Specific Information
This antibody reacts with SHIP-1, a phosphoinositide phosphatase largely confined to hematopoietic cells. Multiple forms of SHIP-1 have been reported with molecular weights of 110, 125, 130, 135, and 145 kDa.
Western Blot: Reducing conditions recommended.
Target Information
This gene belongs to the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression is restricted to hematopoietic cells, where movement from cytosol to plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, it hydrolyzes the 5′ phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, affecting multiple signaling pathways. The protein functions as a negative regulator of myeloid cell proliferation and survival. Alternate transcriptional splice variants encoding different isoforms have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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