Thermo Fisher Scientific PRR7 Monoclonal Antibody (TRAP3/10)

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL
• Publications: View 1 publication

Immunocytochemistry (ICC/IF)

• Tested Dilution: 10 µg/mL
• Publications: View publication

Product Specifications

Product Specific Information

This antibody recognizes an epitope located in the C-terminal part of the intracellular domain of PRR7/TRAP3 (amino acids 126–253 of human PRR7/TRAP3), a 28 kDa proline-rich membrane protein presumably associated with the NMDA receptor complex.

Immunocytochemistry:
Cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton-X100.

Target Information

PRR7/TRAP3 (Proline-rich 7, transmembrane adaptor protein 3) is a 28 kDa transmembrane adaptor protein expressed at low levels in most tissues, with highest expression in the brain. Its amino acid sequence is highly conserved among mammalian species.
PRR7/TRAP3 contains a potential palmitoylation motif and is found in lipid rafts. It is part of the postsynaptic density complex in neurons and associates with PSD-95, NMDA receptor, and other proteins. The intracellular domain includes several tyrosines, a proline-rich sequence, and a C-terminal PDZ-binding motif.
Although its precise function remains unclear, PRR7/TRAP3 may be involved in receptor signaling regulation and the formation of neurologic and immunologic synapses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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