Thermo Fisher Scientific KMT2D Recombinant Rabbit Monoclonal Antibody (9H13L17)
인간 KMT2D 단백질을 인식하는 재조합 토끼 단일클론 항체로 높은 특이성과 민감도를 제공. ICC/IF 및 ChIP 등 다양한 연구 응용에 적합. 로트 간 일관성 유지 및 동물 유래 성분 없는 제형. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
| ChIP assay (ChIP) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9H13L17 |
| Immunogen | Peptides corresponding to Human KMT2D (aa 2–15, 1071–1082) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2633033 |
Product Specific Information
This antibody is predicted to react with Monkey, Cat, Mouse, and Sheep.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation.
KMT2D acts as a coactivator for estrogen receptors by being recruited by ESR1 and activating transcription.
It is involved in chromatin organization, chromatin silencing, oocyte growth, oogenesis, and positive regulation of cell proliferation.
Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1), which results in congenital mental retardation syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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