Thermo Fisher Scientific VDR Recombinant Rabbit Monoclonal Antibody (2R1F6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR SMKRKALFTC PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV QRKREMILKR KEEEALKDSL RPKLSEEQQR IIAILLDAHH KTYDPTYSDF CQFRPPVRVN DGGGSHPSRP NSRHTPSFSG DSSSSCSDHC ITSSDMMDSS SFSNLDLSEE DSDDPSVTLE LSQLSMLPHL ADLVSYSIQK VIGFAKMIPG FRDLTSEDQI VLLKSSAIEV IMLRSNESFT MDDMSWTCGN QDYKYRVSDV

Target Information

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone.
The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors, which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors.

Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have identified VDR in the intestine, bone, kidney, epidermis, and endocrine immune system cells.

Repression of T-cell proliferation and IL-2 gene expression occurs when VDR binds within the IL-2 enhancer. VDR/retinoic X receptor (RXR) heterodimer formation in the presence of intracellular 1,25(OH)₂D₃ interferes with NFATp/Fos/Jun/DNA complex assembly and IL-2 gene transcription.
The corresponding gene for the vitamin D receptor is NR1I1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.