Thermo Fisher Scientific Cardiac Troponin I Recombinant Rabbit Monoclonal Antibody (7B10Q2)
Cardiac Troponin I에 특이적인 재조합 토끼 단클론 항체로, IHC(P)와 ELISA에 사용 가능. 인간 시료 반응성, HEK293 발현 시스템 기반. 고순도 친화 크로마토그래피 정제, 안정적 액상 형태로 -20°C 보관.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7B10Q2 |
| Immunogen | Recombinant protein of human Cardiac Troponin I (TNNI3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.59 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_3093029 |
Target Information
Cardiac Troponin I (TnI, Troponin I) is an integral inhibitory protein in cardiac muscle, forming a complex with troponin C (TnC) and troponin T (TnT).
TnT binds to tropomyosin to form a troponin-tropomyosin complex, anchored by TnI binding to actin within muscle thin filaments.
Calcium binding to TnC induces structural changes that release the inhibitory region of TnI from actin, enabling myosin attachment and muscle contraction.
Blood levels of TnI and TnT serve as diagnostic indicators of cardiac muscle damage and help differentiate angina from myocardial infarction.
Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro.
Mutations in the Cardiac Troponin I gene are associated with familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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