Thermo Fisher Scientific ZEB2 Polyclonal Antibody
ZEB2 단백질을 인식하는 Thermo Fisher Scientific의 염소 폴리클로날 항체로, WB 및 IHC(P) 실험에 적합합니다. 인간 시료 반응성이 있으며, 핵 내 전사 억제 인자 ZEB2 연구에 활용됩니다. 고순도, 안정적인 액상 형태로 제공됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-TDSRRQISNIKKEK (aa 545–558) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933361 |
Product Specific Information
- This antibody is expected to recognize both reported isoforms (NP_055610.1; NP_001165124.1).
- Tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition (EMT), a genetic program controlling cell migration during embryonic development and wound healing.
ZEB2 can protect cells from DNA damage-induced apoptosis, contributing to tumor progression. It is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues.
Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-142715_ZEB2_O60315-1_Goat.svg, PA5-142715_ZEB2_O60315-1_Goat_PDP.jpeg)
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