Thermo Fisher Scientific KV1.2 (KCNA2) Polyclonal Antibody
Rabbit polyclonal antibody targeting Kv1.2 (KCNA2) for WB, ICC/IF, and IP applications. Recognizes voltage-gated potassium channel subunit involved in neuronal excitability. Suitable for mouse samples; supplied as liquid, 1 mg/mL, unconjugated form.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:250–1:500 | - |
| Immunoprecipitation (IP) | 1:10–1:500 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide made to a portion of rat Kv1.2 (within residues 50–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_11152861 |
Product Specific Information
Suggested positive control: HEK293 cell lysate.
Target Information
Kcna2 is a voltage-gated potassium channel (Kv) belonging to the 6-transmembrane (6-TM) family. It includes the Ca²⁺-activated Slo (7-TM) and SK subfamilies. The alpha subunits contain a single pore-forming region and assemble as tetramers. Potassium channels are crucial for regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Four sequence-related potassium channel genes—shaker, shaw, shab, and shal—have been identified in Drosophila, each with human homologs. The Kcna2 gene encodes a voltage-gated, shaker-related potassium channel subunit containing six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, allowing nerve cells to repolarize efficiently after an action potential. The coding region of Kcna2 is intronless and clustered with KCNA3 and KCNA10 on chromosome 1. Diseases associated with KCNA2 include Epileptic Encephalopathy (Early Infantile, 32) and Undetermined Early-Onset Epileptic Encephalopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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