Thermo Fisher Scientific A20A3 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes can lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis.
ANKRD20A (ankyrin repeat domain-containing protein 20A) is an 823 amino acid protein containing five ANK repeats. The gene encoding ANKRD20A maps to chromosome 9, which spans approximately 145 million bases and encodes nearly 900 genes.
Deletion of the distal portion of 9p can result in male-to-female sex reversal (female phenotype with male X,Y genotype). Chromosome 9 abnormalities are also associated with hereditary hemorrhagic telangiectasia and familial dysautonomia, and it is involved in the translocation with chromosome 22 that produces the BCR-ABL fusion protein often found in leukemias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.