Thermo Fisher Scientific A20A3 Polyclonal Antibody
Rabbit polyclonal antibody recognizing A20A3 protein. Validated for WB and IHC(P) in human, mouse, and rat samples. Affinity purified with >95% purity. Supplied in PBS with glycerol and sodium azide for stability. For research use only.
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- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human A20A3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719520 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes can lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis.
ANKRD20A (ankyrin repeat domain-containing protein 20A) is an 823 amino acid protein containing five ANK repeats. The gene encoding ANKRD20A maps to chromosome 9, which spans approximately 145 million bases and encodes nearly 900 genes.
Deletion of the distal portion of 9p can result in male-to-female sex reversal (female phenotype with male X,Y genotype). Chromosome 9 abnormalities are also associated with hereditary hemorrhagic telangiectasia and familial dysautonomia, and it is involved in the translocation with chromosome 22 that produces the BCR-ABL fusion protein often found in leukemias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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