Thermo Fisher Scientific A20A1 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

Ankyrins are membrane adaptor molecules that play key roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations in ankyrin genes can cause severe genetic disorders such as fatal cardiac arrhythmias and hereditary spherocytosis.

ANKRD20A (ankyrin repeat domain-containing protein 20A) is an 823 amino acid protein containing five ANK repeats. The gene encoding ANKRD20A is located on chromosome 9, which spans approximately 145 million bases and encodes nearly 900 genes. This gene may be involved in gender determination, as deletion of the distal portion of 9p can lead to male-to-female sex reversal in individuals with an X,Y genotype.

Additionally, chromosome 9 is associated with disorders such as hereditary hemorrhagic telangiectasia and familial dysautonomia, and participates in the translocation with chromosome 22 that produces the BCR-ABL fusion protein found in certain leukemias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.