Thermo Fisher Scientific KCNQ1 Monoclonal Antibody (N37A/10), FITC
FITC로 표지된 KCNQ1 단클론 항체로 인간, 생쥐, 햄스터, 랫트에서 반응합니다. WB, IHC, ICC 등 다양한 응용 가능. 단백질 G 정제, 1 mg/mL 농도, 4°C 암소 보관. 전압 개폐성 K+ 채널 연구에 적합.
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Thermo Fisher Scientific KCNQ1 Monoclonal Antibody (N37A/10), FITC
Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Immunoprecipitation (IP) | Assay-dependent |
| Antibody Microarray (AM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | N37A/10 |
| Immunogen | Fusion protein amino acids 2–101 of human KCNQ1 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.1 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931862 |
Additional Formats
- Unconjugated (MA5-27676)
- APC (MA5-45407)
- PE (MA5-45410)
- PerCP (MA5-45409)
- Request custom conjugation available
Product Specific Information
1 µg/mL of MA5-45408 was sufficient for detection of KCNQ1 in 10 µg of COS-1 cell lysate transiently expressing KCNQ1 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Detects approximately 75 kDa.
Target Information
Voltage-gated K⁺ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells.
KCNQ1, an alpha subunit, forms a complex with KCNE1, a beta subunit expressed mainly in the heart and cochlea, regulating slow depolarization-activated potassium current.
Mutations in KCNQ1 and KCNE1 lead to cardiac disease due to impaired electrical signaling, while mutations in KCNQ4 are implicated in deafness.
KCNQ proteins, including KCNQ1 and KCNQ4, contain six transmembrane domains and function as tetramers. KCNQ4 forms heteromeric channels with KCNQ3 and is expressed in several tissues, including cochlear outer hair cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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