Thermo Fisher Scientific NR2E1 Monoclonal Antibody (4G12)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

10 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

4G12

Immunogen

NR2E1 (NP_003260, 249 a.a. approximately 342 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TLX,uniProtId:Q9Y466-1,ncbiNodeId:9606,antigenRange:249-342,antigenLength:385,antigenImageFileName:H00007101-M03A_TLX_Q9Y466-1_House_mouse.svg,antigenImageFileNamePDP:H00007101-M03A_TLX_Q9Y466-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Storage buffer

ascites

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: NGDNTDSQKL NKIISEIQAL QEVVARFRQL RLDATEFACL KCIVTFKAVP THSGSELRSF RNAAAIAALQ DEAQLTLNSY IHTRYPTQPC RFGK

Target Information

Nuclear receptor TLX, a NR2 hepatocyte NF4-like receptor, has been shown to affect anterior brain differentiation, retinal development, and vision. It has been suggested that TLX targets genes for RAR beta2 and Pax2 during retinal development. Homozygous TLX mutant mice are viable at birth but exhibit reduced forebrain development and are more aggressive than wild-type mice. Mice with deleted TLX locus exhibit cerebral hypoplasia, blindness, and extreme aggression (fierce (frc) phenotype). TLX expression has been documented in mouse brain and eye. ESTs have been isolated from normal human brain libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.