Thermo Fisher Scientific SHFM3 Polyclonal Antibody
Human SHFM3 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC(P), ICC/IF 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보존. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SHFM3. Recombinant protein control fragment (Product #RP-95598). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.08 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647272 |
Product Specific Information
Immunogen sequence:
QCLHTIQTED RVWSIAISPL LSSFVTGTAC CGHFSPLRIW DLNSGQLMTH LGSDFPPGAG VLDVMYESPF TLLSCGYD
Sequence identity:
- Mouse: 97%
- Rat: 95%
Target Information
This gene belongs to the F-box/WD-40 gene family, which recruits specific target proteins through WD-40 domains for ubiquitin-mediated degradation. In mouse, a similar protein maintains the apical ectodermal ridge during limb bud development. Disruption of the gene leads to absence of central digits and syndactyly, resembling human split hand-split foot malformation. This condition is genetically heterogeneous, with various inheritance modes. An autosomal recessive form maps to the same chromosomal region, and complex rearrangements involving duplications of this gene are associated with the disorder. A pseudogene is located within an intron of the BCR gene on chromosome 22.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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