Thermo Fisher Scientific ENPP4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:25–1:100

Product Specifications

Product Specific Information

The antibody detects endogenous levels of total ENPP4 protein.

Target Information

NPP4, also known as ENPP4 (ectonucleotide pyrophosphatase/phosphodiesterase family member 4), is a 453 amino acid single-pass type I membrane protein belonging to the nucleotide pyrophosphatase/phosphodiesterase family.
The gene encoding NPP4 spans approximately 16,736 bases and maps to human chromosome 6p21.1. Chromosome 6 comprises about 6% of the human genome, containing roughly 1,200 genes within 170 million base pairs.
Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting a cancer susceptibility locus. Porphyria cutanea tarda is linked to chromosome 6 through the HFE gene, and Stickler syndrome, 21-hydroxylase deficiency, and maple syrup urine disease are also associated with genes on this chromosome.
Notably, the PARK2 gene (related to Parkinson’s disease) and genes encoding major histocompatibility complex proteins are located on chromosome 6. A bipolar disorder susceptibility locus has also been identified on the q arm of chromosome 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.