Thermo Fisher Scientific NMDAR2B Chimeric Recombinant Rabbit Monoclonal Antibody (17)
Rat GluN2B ATD에 특이적으로 반응하는 재조합 토끼 단클론 항체. ICC, Flow Cytometry, In vitro assay에 사용 가능. Protein A 정제 및 PBS buffer에 1 mg/mL 농도로 제공. 신경세포 발달 및 기억 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
| In vitro Assay (IV) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 17 |
| Immunogen | Monoclonal antibodies that bind rat GluN2B ATD were obtained by immunizing mice with the purified intact GluN1-GluN2B NMDA receptors. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
Reacts specifically with rat GluN2B ATD.
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. These receptors are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency related to memory and learning.
NMDARs play a role in neuronal development and are implicated in several central nervous system disorders, including Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
Overexpression of the NR2B subunit is associated with enhanced learning and memory, while reduced NR2B expression is observed in aged, memory-impaired animals. Phosphorylation of Tyr1472 on NR2B may increase NMDAR expression at synapses, contributing to synaptic plasticity.
NMDAR2B forms part of a heterotrimeric complex with NR1, NR2, and NR3 subunits. Dysfunctions in NMDAR2B are linked to epileptic encephalopathy and autosomal dominant 6-related intellectual disability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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