Thermo Fisher Scientific SARS-CoV-2 Spike Protein (RBD) Chimeric Recombinant Mouse Monoclonal Antibody (Sb#16)
SARS-CoV-2 스파이크 단백질 RBD에 특이적으로 결합하는 키메라형 마우스 단클론 항체입니다. ELISA 및 기능적 억제 실험에 사용 가능합니다. HEK293 세포에서 발현된 재조합 항체로, Protein A로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| ELISA | 1 µg/mL | |
| Functional Assay | Assay-dependent | |
| Inhibition Assay | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Virus |
| Host / Isotype | Mouse / IgG1, Fc |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Sb#16 |
| Immunogen | This clone was originally isolated in a form of a synthetic nanobody (sybody) via a target swap selection procedure against RBD-vYFP using ribosomal display and against RBD-Fc fusion during phage display rounds. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody recognizes and binds the SARS-CoV-2 C-terminal receptor binding domain (RBD) located in the extracellular portion of the spike protein.
Target Information
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), also known as 2019-nCoV (2019 Novel Coronavirus), is a virus that causes illnesses ranging from mild cold-like symptoms to severe respiratory distress and death.
The coronavirus Spike (S) protein plays a crucial role in viral attachment, fusion, and entry, and serves as a major target for antibody, inhibitor, and vaccine development.
The receptor-binding domain (RBD, S-RBD) of the SARS-CoV-2 Spike protein binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. Compared to SARS-CoV, the SARS-CoV-2 RBD exhibits higher binding affinity to ACE2. The S1 subunit contains the RBD that specifically interacts with ACE2 on target cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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