Thermo Fisher Scientific SHH Monoclonal Antibody (5H4)
SHH 단백질을 검출하기 위한 Thermo Fisher Scientific의 5H4 클론 단일클론 항체입니다. Western blot, IHC, Flow cytometry, ELISA 등 다양한 응용에 사용 가능하며 Human, Mouse, 비인간 영장류 반응성을 보입니다. 정제된 재조합 SHH 단편(aa 26–161)을 면역원으로 사용한 고품질 항체입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5H4 |
| Immunogen | Purified recombinant fragment of human SHH (amino acids 26–161) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538644 |
Product Specific Information
MA5-17173 targets SHH in indirect ELISA, FACS, IHC, and WB applications and shows reactivity with Human, Mouse, and Non-human primate samples.
The immunogen is a purified recombinant fragment of human SHH (amino acids 26–161) expressed in E. coli.
MA5-17173 detects SHH with a predicted molecular weight of approximately 49.6 kDa.
Target Information
Sonic Hedgehog (SHH) is expressed only during embryogenesis and plays a crucial role in early embryo patterning. It acts as a key inductive signal in the development of the ventral neural tube, anterior-posterior limb axis, and ventral somites.
The SHH protein is synthesized as a precursor that undergoes autocatalytic cleavage. The N-terminal portion is soluble and responsible for signaling activity, while the C-terminal portion mediates precursor processing and attaches a cholesterol moiety to the N-terminal product, restricting its diffusion.
Defects in SHH or its signaling pathway can cause holoprosencephaly (HPE), characterized by improper forebrain separation and facial deformities. Mutations may also be associated with VACTERL syndrome, involving vertebral, anal, tracheoesophageal, renal, cardiac, and limb abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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