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ELK Biotechnology TAL1 (phospho Ser122) rabbit pAb
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TAL1 (phospho Ser122) rabbit polyclonal antibody로, 인산화된 Ser122 부위를 인식합니다. WB, IHC, IF, ELISA에 사용 가능하며, 인간 및 생쥐 시료에 반응합니다. 핵 단백질 TAL1의 발현 및 인산화 연구에 적합합니다.
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ELK Biotechnology ES7342-100UL TAL1 (phospho Ser122) rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES7342-50UL TAL1 (phospho Ser122) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology TAL1 (phospho Ser122) rabbit pAb
제품명
TAL1 (phospho Ser122) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TAL1; BHLHA17; SCL; TCL5; T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human TAL-1 around the phosphorylation site of Ser122 (AA range: 96–145) |
| Host Species | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 45 kDa |
| Gene ID (Human) | 6886 |
| Human Swiss-Prot No. | P17542 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse |
Background
- Alternative products: The splicing pattern is cell-lineage dependent.
- Disease relevance: A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.
- Domain: The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
- Function: Implicated in the genesis of hemopoietic malignancies; may play an important role in hemopoietic differentiation and act as a positive regulator of erythroid differentiation.
- PTM: Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia. Ubiquitinated following hypoxia-dependent phosphorylation of Ser-122, leading to rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells.
- Similarity: Contains one basic helix-loop-helix (bHLH) domain.
- Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3; binds to LMO2 and DRG1; can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1, and TCF3.
- Tissue specificity: Leukemic stem cell.
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