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ELK Biotechnology COP1 (phospho Ser387) rabbit pAb
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인간 RFWD2 단백질의 Ser387 인산화 부위에 특이적인 rabbit polyclonal antibody로, WB와 ELISA에 적합합니다. 핵과 세포질에서 COP1 단백질 검출에 사용되며, p53 및 JUN 관련 단백질 유비퀴틴화 연구에 활용됩니다.
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- pk
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ELK Biotechnology ES7161-100UL COP1 (phospho Ser387) rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES7161-50UL COP1 (phospho Ser387) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology COP1 (phospho Ser387) rabbit pAb
제품명
COP1 (phospho Ser387) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RFWD2; COP1; RNF200; E3 ubiquitin-protein ligase RFWD2; Constitutive photomorphogenesis protein 1 homolog; hCOP1; RING finger and WD repeat domain protein 2; RING finger protein 200 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human RFWD2 around the phosphorylation site of Ser387 (AA range: 353–402) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 100 kD |
| GeneID (Human) | 64326 |
| Human Swiss-Prot No | Q8NHY2 |
| Cellular Localization | Nucleus speckle, Cytoplasm. In the nucleus, it forms nuclear speckles. |
| Species Reactivity | Human; Mouse |
단백질 배경 정보
- Domain: The RING finger domain functions as a structural scaffold, bringing two clusters of positively charged residues close together to mimic a bipartite nuclear localization signal (NLS).
- Function: E3 ubiquitin-protein ligase mediating ubiquitination and proteasomal degradation of target proteins such as JUN and p53 (TP53). It abolishes p53-dependent transcription and apoptosis by ubiquitinating p53 independently of MDM2 or RCHY1.
- Pathway: Protein modification; protein ubiquitination.
- Similarity: Belongs to the COP1 family; contains 1 RING-type zinc finger and 7 WD repeats.
- Subunit: Forms homodimers via coiled coil domain. Component of DCX DET1-COP1 ubiquitin ligase complex (RBX1, DET1, DDB1, CUL4A, COP1). Isoform interactions vary with CUL proteins. Interacts with JUN, JUNB, JUND, and p53 (TP53).
- Tissue Specificity: Ubiquitously expressed at low level; higher expression in testis, placenta, skeletal muscle, and heart.
- Induction: By p53/TP53.
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