ELK Biotechnology BRCA1 (phospho Ser1524) rabbit pAb
BRCA1 인산화(Ser1524) 부위를 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA 등에 사용 가능. DNA 손상 반응 및 종양 억제 관련 연구에 적합. 인체, 생쥐, 랫트 시료에 반응. -20°C 보관, 1 mg/ml 농도.
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BRCA1 (phospho Ser1524) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | BRCA1 (phospho Ser1524) rabbit pAb |
| Alternative Names | BRCA1; RNF53; Breast cancer type 1 susceptibility protein; RING finger protein 53 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BRCA1 around the phosphorylation site of Ser1524. AA range: 1491-1540 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 672 |
| Human Swiss-Prot No | P38398 |
| Cellular Localization | Nucleus, Chromosome, Cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by ABRAXAS1 and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719). Isoform 3: Cytoplasm; Isoform 5: Cytoplasm. |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II and interacts with histone deacetylase complexes through its C-terminal domain. It plays roles in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers. Alternative splicing affects subcellular localization and physiological function, producing many transcript variants.
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