ELK Biotechnology TGIF rabbit pAb
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| Product name: | TGIF rabbit pAb |
| Alternative Names: | TGIF1; TGIF; Homeobox protein TGIF1; 5-TG-3-interacting factor 1 |
| Applications: | WB;ELISA |
| Recommended Dilutions: | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human TGIF. |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 43kD |
| GeneID（Human）: | 7050 |
| Human Swiss-Prot No: | Q15583 |
| Cellular localization: | Nucleus. |
| Background: | The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provide |
| Species Reactivity: | Human;Mouse;Rat |
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