Thermo Fisher Scientific SR-BI/SR-BII Polyclonal Antibody
SR-BI/SR-BII 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat 시료에 반응합니다. WB, IHC, ICC/IF, Flow, IP 등 다양한 응용 가능. HDL 관련 지질 전달 연구에 적합하며, 장기 보관 시 -20°C에서 안정적입니다.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1:50–1:1,000 |
| Flow Cytometry (Flow) | 1:400 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from the extracellular domain (residues 230–380) of Scavenger Receptor-BI/BII expressed as two tandem copies in bacteria using the pET system |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1960595 |
Product Specific Information
The PA1-32415 immunogen is a synthetic peptide derived from the extracellular domain (residues 230–380) of Scavenger Receptor-BI/BII, expressed as two tandem copies in bacteria using the pET system.
Store product as a concentrated solution and centrifuge briefly prior to opening the vial.
Target Information
High density lipoproteins (HDLs) are key regulators of cholesterol metabolism, with plasma concentrations inversely correlated to atherosclerosis risk.
SR-BI and SR-BII (also known as SR-BI.2) are alternatively spliced variants of the same gene, differing only in their C-terminal cytoplasmic domain.
Both bind HDL and mediate selective uptake of HDL cholesteryl ester, with SR-BII showing ~4-fold lower efficiency than SR-BI.
These receptors are mainly expressed in liver and steroidogenic tissues.
SR-BII mRNA arises from alternative splicing of SR-BI precursor transcripts, both isoforms mediating selective lipid transfer between HDL and cells.
Relative expression and activity of SR-BI and SR-BII may regulate lipid exchange between HDL and cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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