Thermo Fisher Scientific NUMB Polyclonal Antibody
Rabbit 폴리클로날 항체로서 NUMB 단백질을 검출하며 Western blot과 Immunocytochemistry에 사용 가능. Mouse 및 Human 시료에 반응. 액상 형태로 제공되며 2 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide made to a C-terminal region of mouse NUMB (between residues 600–653). [UniProt# Q9QZS3] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2154283 |
Product Specific Information
PA1-32452 detects Numb from mouse and human samples.
Target Information
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca²⁺ channel (VGCC) inhibitor or by Ca²⁺ chelator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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