Thermo Fisher Scientific NUMB Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.2-0.5 µg/mL

-

Immunocytochemistry (ICC/IF)

1:500

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide made to a C-terminal region of mouse NUMB (between residues 600-653). [UniProt# Q9QZS3] if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NUMB,uniProtId:Q9QZS3-1,ncbiNodeId:10090,antigenRange:600-653,antigenLength:653,antigenImageFileName:PA1-32452_NUMB_Q9QZS3-1_Rabbit.svg,antigenImageFileNamePDP:PA1-32452_NUMB_Q9QZS3-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2154283

Product Specific Information

PA1-32452 detects Numb from mouse, human samples.

Target Information

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.