Thermo Fisher Scientific UFD1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000
• Publications: []

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate
• Publications: []

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

Ubiquitin-mediated proteolysis involves the transfer of ubiquitin (Ub) to lysine residues on cellular proteins, leading to their degradation by the 26S proteasome. Ub-fusions are cleaved by Ub-specific processing proteases (UBps) or by the Ub-fusion degradation (UFD) pathway.
UFD1 was first identified in S. cerevisiae and later in humans as UFD1L. It modulates degradation of Ub-fusions with amino acid substitutions at Gly76 by promoting selective multiubiquitination. Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting a link between this proteolytic pathway and developmental abnormalities.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.