Thermo Fisher Scientific UFD1 Polyclonal Antibody
Rabbit polyclonal antibody against human UFD1, validated for WB and IP applications. Recognizes residues 175–225 of UFD1L. Supplied as an unconjugated liquid at 0.2 mg/mL. For research use only; store at 4°C with 1-year shelf life.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
- Publications: []
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
- Publications: []
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 175 and 225 of Human ubiquitin fusion degradation 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Ubiquitin-mediated proteolysis involves the transfer of ubiquitin (Ub) to lysine residues on cellular proteins, leading to their degradation by the 26S proteasome. Ub-fusions are cleaved by Ub-specific processing proteases (UBps) or by the Ub-fusion degradation (UFD) pathway.
UFD1 was first identified in S. cerevisiae and later in humans as UFD1L. It modulates degradation of Ub-fusions with amino acid substitutions at Gly76 by promoting selective multiubiquitination. Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting a link between this proteolytic pathway and developmental abnormalities.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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