Thermo Fisher Scientific UFD1 Polyclonal Antibody
Thermo Fisher Scientific의 UFD1 Polyclonal Antibody는 인간 UFD1 단백질을 인식하는 토끼 유래 다클론 항체입니다. Western blot 및 Immunoprecipitation에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- A301875A
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 175 and 225 of Human ubiquitin fusion degradation 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Ubiquitin-mediated proteolysis involves the transfer of ubiquitin (Ub) to lysine groups on target proteins, promoting their degradation by the 26S proteasome. Ub-fusions are processed by Ub-specific proteases (UBps) or via the Ub-fusion degradation (UFD) pathway.
The UFD1 protein, initially identified in S. cerevisiae, has a human homolog known as UFD1L. In vitro, UFD1 modulates degradation of Ub-fusions with amino acid substitutions at the Gly76 site by selective multiubiquitination.
Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting a role of this proteolytic pathway in developmental processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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