Thermo Fisher Scientific UFD1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

Ubiquitin-mediated proteolysis involves the transfer of ubiquitin (Ub) to lysine groups on target proteins, promoting their degradation by the 26S proteasome. Ub-fusions are processed by Ub-specific proteases (UBps) or via the Ub-fusion degradation (UFD) pathway.
The UFD1 protein, initially identified in S. cerevisiae, has a human homolog known as UFD1L. In vitro, UFD1 modulates degradation of Ub-fusions with amino acid substitutions at the Gly76 site by selective multiubiquitination.
Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting a role of this proteolytic pathway in developmental processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.