Thermo Fisher Scientific UFD1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat

Target Information

Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, leading to their degradation by the 26S proteasome. Ub-fusions are processed by Ub-specific proteases (UBps) or by the Ub-fusion degradation (UFD) pathway. UFD1, initially identified in yeast S. cerevisiae, has a human homolog UFD1L that modulates degradation of Ub-fusions containing substitutions at Gly76. Mutations in the UFD1 gene are associated with CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, indicating a role in developmental processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일: A301-876A-M_UFD1L_Q92890-2_Rabbit.svg, A301-876A-M_UFD1L_Q92890-2_Rabbit_PDP.jpeg)