Thermo Fisher Scientific UBE2T Polyclonal Antibody
Rabbit polyclonal antibody targeting human UBE2T, suitable for WB and IP applications. Recognizes region 147–197 of UBE2T. Supplied as liquid, unconjugated form, 0.20 mg/mL concentration. For research use only.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 147 and 197 of Human ubiquitin-conjugating enzyme E2T |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
UBE2T is involved in the covalent conjugation of ubiquitin to proteins, regulating diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through the concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2) such as UBE2T, and a ubiquitin ligase (E3).
UBE2T catalyzes the covalent attachment of ubiquitin to protein substrates, accepts ubiquitin from the E1 complex, and catalyzes its covalent attachment to other proteins. It is involved in mitomycin-C (MMC)-induced DNA repair and catalyzes monoubiquitination of FANCD2, a key step in the DNA damage pathway.
Defects in the UBE2T gene have been associated with Fanconi anemia of complementation group T.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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