Thermo Fisher Scientific Phospho-Doublecortin (Ser297) Polyclonal Antibody
Doublecortin 단백질의 Ser297 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 검증 완료. 인간, 마우스, 랫트 반응성. 1 mg/mL 농도의 액상형으로, PBS/glycerol buffer에 보관. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DCX (Accession O43602), corresponding to amino acid residues around phosphorylated Ser297. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816064 |
Product Specific Information
This antibody detects endogenous levels of Doublecortin only when phosphorylated at Ser297.
Target Information
Doublecortin (DCX) is a cytoplasmic protein that regulates neuronal migration by organizing and stabilizing microtubules in the developing cortex. It contains two doublecortin domains that bind microtubules and interacts with LIS1, a regulatory subunit of platelet activating factor acetylhydrolase, which is essential for proper microtubule function. Mutations in the DCX gene are associated with X-linked lissencephaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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