Thermo Fisher Scientific Phospho-DR6 (Ser562) Polyclonal Antibody
Phospho-DR6 (Ser562) 특이적 인식 항체로 인간 및 생쥐 시료에서 사용 가능. Western blot과 IHC(Paraffin) 실험에 적합. 액상 형태로 1 mg/mL 농도, -20°C 저장. 연구용으로만 사용.
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- PA5104590
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNFRSF21 (Accession O75509), corresponding to amino acid residues around phosphorylated Ser562 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816065 |
Product Specific Information
Antibody detects endogenous levels of DR6 only when phosphorylated at Ser562.
Target Information
DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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