Thermo Fisher Scientific ADAM15 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs, approximately 10% cross-reactivity with recombinant mouse ADAM15 is observed.
• Less than 1% cross-reactivity is observed with rmADAM9, rmADAM10, rhADAM8, rhADAM9, rhADAM10, rhADAM12, rhADAM17 (TACE), rhADAM19, rhADAM22, rhADAM23, rhADAM32, and rhADAM33.
• Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

The ADAM15 protein belongs to the ADAM (a disintegrin and metalloproteinase) family, which includes type I transmembrane glycoproteins involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules.
It contains multiple functional domains, including a zinc-binding metalloprotease domain, a disintegrin-like domain, and an EGF-like domain.
Through its disintegrin-like domain, ADAM15 interacts specifically with the integrin beta chain (β3) and Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting roles in cell-cell adhesion and signal transduction.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.