Thermo Fisher Scientific ADAM15 Polyclonal Antibody
ADAM15 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 다클론 항체. Western blot, IHC(P), IP 등에 사용 가능. 인간 시료 반응성. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 상태로 제공. 연구용으로만 사용.
- 카탈로그번호
- PA547966
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–15 µg/mL |
| Immunoprecipitation (IP) | 25 µg/mL |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Sf21-derived recombinant human ADAM15 Ectodomain (Leu18–Ser693) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607932 |
Product Specific Information
- In direct ELISAs, approximately 10% cross-reactivity with recombinant mouse ADAM15 is observed.
- Less than 1% cross-reactivity is observed with rmADAM9, rmADAM10, rhADAM8, rhADAM9, rhADAM10, rhADAM12, rhADAM17 (TACE), rhADAM19, rhADAM22, rhADAM23, rhADAM32, and rhADAM33.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
The ADAM15 protein belongs to the ADAM (a disintegrin and metalloproteinase) family, which includes type I transmembrane glycoproteins involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules.
It contains multiple functional domains, including a zinc-binding metalloprotease domain, a disintegrin-like domain, and an EGF-like domain.
Through its disintegrin-like domain, ADAM15 interacts specifically with the integrin beta chain (β3) and Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting roles in cell-cell adhesion and signal transduction.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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