Thermo Fisher Scientific MYH9 Polyclonal Antibody
MYH9 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Western Blot, IHC, ELISA에 사용 가능. 인간 및 마우스 반응성. 액상 형태, 0.65 mg/mL 농도, -20°C 보관. 세포골격 연구 및 MYH9 관련 질환 연구용.
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Thermo Fisher Scientific MYH9 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1711–1960 of human MYH9 (NP_0024641) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.65 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804095 |
Product Specific Information
Immunogen Sequence:
ANSSGKGALA LEEKRRLEAR IAQLEEELEE EQGNTELIND RLKKANLQID QINTDLNLER SHAQKNENAR QQLERQNKEL KVKLQEMEGT VKSKYKASIT ALEAKIAQLE EQLDNETKER QAACKQVRRT EKKLKDVLLQ VDDERRNAEQ YKDQADKAST RLKQLKRQLE EAEEEAQRAN ASRRKLQREL EDATETADAM NREVSSLKNK LRRGDLPFVV PRRMARKGAG DGSDEEVDGK ADGAEAKPAE
Positive Samples: HeLa, Jurkat, LO2, SW480, Mouse liver, Mouse lung
Cellular Location: Cytoplasm, cell cortex, cytoskeleton
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a key component of the actin cytoskeleton. It spans over 106 kilobases and includes 41 exons encoding a 1,960 amino acid protein. NMHC IIA forms a hexameric complex with two heavy chains, two regulatory light chains, and two essential light chains.
This protein interacts with actin filaments and is involved in cell migration, adhesion, division, and maintenance of cell shape. Mutations in MYH9 cause MYH9-related diseases (MYH9-RD) such as May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome, characterized by macrothrombocytopenia and potential complications including hearing loss, renal failure, and cataracts.
MYH9 is essential in hematopoiesis for the survival and maintenance of hematopoietic stem and progenitor cells (HSPCs). Loss of MYH9 function disrupts normal hematopoiesis, leading to severe blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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