Thermo Fisher Scientific CD26 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–0.5 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 5 µg/mL

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

CD26 (dipeptidyl peptidase IV, DPP IV, adenosine deaminase binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family.
CD26 is expressed on lymphocytes and upregulated during T-cell activation. It is also found on activated B cells, natural killer cells, and epithelial tissues.
CD26 participates in T-cell activation, cell adhesion to extracellular matrix components such as fibronectin and collagen, and HIV infection.
It is identical to adenosine deaminase complexing protein-2 and functions as a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.
Alterations in CD26 peptidase activity are associated with malignant transformation, with activity increasing with tumor grade and severity.
Changes in CD26 density have been observed on circulating monocytes and CD4+ T cells in rheumatoid arthritis and systemic lupus erythematosus.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.