Thermo Fisher Scientific Phospho-Connexin 43 (Ser368) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Connexin 43 (GJA1) only when phosphorylated at Serine 368.

Target Information

Connexin 43 (Cx43) is a member of the gap junction protein family. Connexins assemble as hexamers and are transported to the plasma membrane to form hemichannels that connect adjacent cells, creating cell-to-cell communication pathways known as gap junctions.
Phosphorylation of Cx43, particularly at Ser368 by protein kinase C (PKC) upon phorbol ester activation, modulates gap junction assembly and function by decreasing intercellular communication. Src kinase can also interact with and phosphorylate Cx43, altering junctional communication.

Cx43 is the predominant gap junction protein in the heart, playing a critical role in synchronized cardiac contraction and embryonic development. It is regulated by several kinases that modulate myocardial cell coupling. A related intron-less pseudogene, GJA1P, is mapped to chromosome 5.

Mutations in gap junction-related genes are associated with disorders such as X-linked Charcot-Marie-Tooth disease, oculodentodigital dysplasia, and cardiac malformations.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

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