Thermo Fisher Scientific Phospho-PKC Pan (Thr497) Polyclonal Antibody
PKC-pan 단백질의 Thr497 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합하며, 인간, 마우스, 랫트 시료에 반응. 세포 성장 및 신호전달 연구에 활용 가능.
- 카탈로그번호
- PA5104818
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRKCA (Accession P17252), corresponding to amino acid residues around phosphorylated Thr497 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816291 |
Product Specific Information
This antibody detects endogenous levels of PKC-pan only when phosphorylated at Threonine 497.
Target Information
Members of the protein kinase C (PKC) family play key regulatory roles in various cellular functions, including cell growth and differentiation, gene expression, hormone secretion, and membrane function. PKCs are serine/threonine kinases dependent on calcium and phospholipids for activity. Diacylglycerols (DAG) and tumor-promoting phorbol esters bind to and activate PKC.
PKCs can be subdivided into two major classes:
- Conventional (cPKC): α, βI, βII, γ
- Novel (nPKC): δ, ε, ζ, η, θ
Expression patterns differ among tissues, and PKC isoforms exhibit distinct cofactor dependencies. For example, kinase activities of nPKC δ and ε are independent of Ca²⁺.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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