Thermo Fisher Scientific PTPN22 Polyclonal Antibody
PTPN22 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western blot 및 Immunocytochemistry에 사용 가능하며, 고순도(>95%) 항체로 연구용에 적합합니다.
- 판매단위
- pk
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Thermo Fisher Scientific PTPN22 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length human PTPN22 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2554046 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 92 kDa
- Purity >95% by SDS-PAGE
Target Information
The protein tyrosine phosphatase PTPN22 (PTP22, LYP, PEP, formerly PTPN8) is a genetic variant associated with risk for autoimmune diseases such as type 1 diabetes and rheumatoid arthritis.
The minor allele of a missense SNP in PTPN22 encodes a hematopoietic-specific protein tyrosine phosphatase known as Lyp.
This risk allele is found in ~17% of Caucasian individuals and ~28% of those with rheumatoid arthritis.
It may disrupt the P1 proline-rich motif crucial for interaction with the SH3 domain of CSK, potentially altering normal T cell regulation.
PTPN22 is suggested to act as an effector or regulator of CSK in T cells and other hematopoietic cells.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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