Thermo Fisher Scientific LETMD1 Polyclonal Antibody
LETMD1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length human LETMD1 (amino acids 1–360) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2554045 |
Product Specific Information
- Detects endogenous LETMD1 protein at ~42 kDa.
- Purity: >95% by SDS-PAGE.
Target Information
HCCR-1 (human cervical cancer oncogene 1), also known as HCCR-2 or LETMD1, is a 360-amino-acid single-pass membrane protein expressed in kidney, liver, skeletal muscle, heart, and brain.
It may be involved in tumorigenesis and function as a negative regulator of the p53 tumor suppressor.
Overexpression can cause mitochondrial dysfunction, leading to apoptosis resistance and tumor progression.
HCCR-1 is considered a candidate biomarker for breast cancer and is highly expressed in various human tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon, and uterine cervix.
Six isoforms exist due to alternative splicing events.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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