Thermo Fisher Scientific Ataxin 1 Polyclonal Antibody
Ataxin 1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합. 사람, 생쥐, 랫트 반응성. 합성 펩타이드 항원 기반, 동결건조 형태로 제공되며 장기 보관 시 -20°C 권장. 연구용 전용 제품.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of human Ataxin 1 (Spinocerebellar ataxia type 1 protein) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Ataxin-1.
Target Information
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem, and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I–III.
ADCAI is genetically heterogeneous, with five genetic loci designated spinocerebellar ataxia (SCA) 1, 2, 3, 4, and 6, assigned to different chromosomes.
ADCAII presents with retinal degeneration (SCA7), and ADCAIII, often referred to as the ‘pure’ cerebellar syndrome (SCA5), are more homogeneous disorders.
ADCA is caused by expansion of CAG repeats, producing elongated polyglutamine tracts in proteins. The expanded repeats are unstable and increase through generations.
This locus is mapped to chromosome 6, with diseased alleles containing 41–81 CAG repeats (normal: 6–39), associated with spinocerebellar ataxia type 1 (SCA1).
At least two transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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