Thermo Fisher Scientific APP Polyclonal Antibody
APP 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 사용 가능. Human, Mouse, Rat에 반응하며, 동결건조 형태로 제공. Alzheimer’s disease 연구 등 신경 관련 단백질 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human Amyloid beta A4 protein (region 350–450) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: APP (Amyloid Precursor Protein)
Target Information
Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating axonal transport of beta-secretase and presenilin 1. It is essential for neurite growth, neuronal adhesion, and axonogenesis.
APP (100–140 kDa) is a transmembrane glycoprotein with multiple isoforms from alternative splicing. Proteolytic cleavage by beta- and gamma-secretases generates beta amyloid, a major component of senile plaques, characteristic of Alzheimer’s disease.
Abnormal APP regulation is associated with Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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