Thermo Fisher Scientific AQP2 Polyclonal Antibody
Aquaporin 2 단백질을 인식하는 염소 유래 polyclonal 항체로, Western blot 및 Immunohistochemistry에 적합. 인간, 마우스, 랫트 반응성. 동결건조 형태로 제공되며 장기 보관 시 -20°C 권장. 연구용으로만 사용 가능.
- 카탈로그번호
- OSA00145W-100UL
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from human Aquaporin 2 conjugated to blue carrier protein, located in aa region 200–260 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: AQP2.
Target Information
Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct.
Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans.
Vasopressin induces cAMP increase, resulting in phosphorylation of AQP2 at serine-256 and its translocation to the apical membrane of principal cells.
Serine-261 has been identified as a novel phosphorylation site, with phosphorylated S261 levels decreasing upon vasopressin treatment, suggesting involvement in vasopressin-dependent AQP2 trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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