Thermo Fisher Scientific CaV1.2a (CACNA1C) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200

Immunohistochemistry (IHC)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Reconstitution: Add 25 µL, 50 µL, or 0.2 mL double distilled water (DDW) depending on sample size.
• Ships as lyophilized powder at room temperature; store at -20°C upon arrival.
• Reconstituted solution can be stored at 4°C for up to 1 week; for longer storage, aliquot and keep at -20°C.
• Avoid repeated freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

CACNA1C encodes the alpha-1 subunit of a voltage-dependent calcium channel.
Calcium channels mediate calcium ion influx upon membrane polarization.
The alpha-1 subunit has 24 transmembrane segments and forms the ion-conducting pore.
The functional channel complex includes alpha-1, alpha-2/delta, beta, and gamma subunits (1:1:1:1 ratio).
Multiple isoforms arise from distinct genes or alternative splicing events.
The CACNA1C protein binds to and is inhibited by dihydropyridine.
Alternative splicing produces diverse transcript variants encoding different proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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