Thermo Fisher Scientific NOTCH2 Polyclonal Antibody
Rabbit polyclonal antibody against human NOTCH2 protein. Validated for WB, IHC, and ELISA applications. Supplied as a liquid form at 1 mg/mL, purified by antigen affinity chromatography. Suitable for research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:2,000 |
| Immunohistochemistry (IHC) | 1:10–1:500 |
| ELISA | 1:100–1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide representing the C-terminal region of the human NOTCH homolog 2 (NOTCH2) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154292 |
Target Information
Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved protein involved in the Notch signaling pathway. It is a type I transmembrane protein with an extracellular domain containing multiple EGF-like repeats and an intracellular domain with several functional regions. NOTCH2 acts as a receptor for membrane-bound ligands such as Jagged1, Jagged2, and Delta1, playing a key role in regulating cell-fate determination. Mutations in NOTCH2 can cause Alagille syndrome type 2 (ALGS2), an autosomal dominant multisystem disorder characterized by hepatic bile duct paucity, cholestasis, and associated cardiac, skeletal, and ophthalmologic abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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