Thermo Fisher Scientific TRAF3IP2 Polyclonal Antibody

Applications

• Western Blot (WB): 1:100–1:2,000

Product Specifications

Product Specific Information

• Suggested positive control: antigen standard for TRAF3IP2 (transient overexpression lysate).

Target Information

This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals, and stress.
The gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase.
Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein-encoding transcripts, suggesting it has a regulatory role in the expression of this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.