Thermo Fisher Scientific GTF2IRD/TFII-IRD1 Polyclonal Antibody
Thermo Fisher Scientific의 GTF2IRD/TFII-IRD1 Polyclonal Antibody는 인간 GTF2IRD1 단백질을 인식하는 Rabbit IgG 항체입니다. Western blot, IHC, IP 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 909 and 959 of human general transcription factor 2I repeat domain containing 1 (GTF2IRD1, UniProt ID: Q9UHL9-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
Target Information
Williams-Beuren syndrome (WBS) is a developmental disorder caused by a hemizygous microdeletion on chromosome 7q11.23. It is characterized by distinctive physical, cognitive, and behavioral traits, including facial dysmorphology, vascular stenoses, growth deficiencies, dental anomalies, and neurological abnormalities.
The WBSCR11 gene, also known as GTF2IRD1, GRF2IRD1, GTF3, Cream1, and MusTRD1 in humans, and BEN in mice, is located within the WBS deletion region. Loss of this transcription factor may contribute to developmental symptoms associated with WBS. WBSCR11 is expressed in all adult tissues as several variants and shows discrete spatial and temporal expression during embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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