Thermo Fisher Scientific Human PHKG2, GST Tag Recombinant Protein

Thermo Fisher Scientific Human PHKG2, GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Product Specifications

Product Specific Information

For maximum recovery, please spin prior to use.
Unless noted below, aliquots of the 5 µg, 10 µg, and 20 µg sizes of kinase are not recommended, as materials can be used in original packaging until exhausted.
For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots; aliquots below 20 µL are not recommended.
Please never store a kinase diluted.
If properly stored at -80°C, this product is guaranteed for 6 months from date of purchase.

Protein Form: Full Length

Target Information

PHKG2 is a testis/liver isoform of the phosphorylase kinase gamma subunit.
Phosphorylase kinase is a polymer of 16 subunits — four each of alpha, beta, gamma, and delta.

• Alpha subunit: skeletal muscle and hepatic isoforms (two different genes)
• Beta subunit: same in both isoforms (one gene)
• Gamma subunit: includes skeletal muscle and hepatic isoforms; hepatic isoform encoded by PHKG2
• Delta subunit: calmodulin, encoded by three different genes

The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation.
The delta subunit mediates calcium dependence of the enzyme.
Mutations in PHKG2 cause glycogen storage disease type 9C (autosomal liver glycogenosis).
Alternatively spliced transcript variants encoding different isoforms have been identified in PHKG2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.