Thermo Fisher Scientific POMGNT1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total MGAT1.

Target Information

The POMGNT1 gene encodes protein O-mannose beta-1,2-N-acetylglucosaminyltransferase, which participates in O-mannosyl glycan synthesis. POMGnT1 is a type II membrane protein localized in the medial-Golgi that initiates the conversion of high mannose N-glycans to complex N-glycans. It acts as a glycosylation enzyme involved in the synthesis of O-mannosyl glycan, a laminin-binding ligand of alpha-dystroglycan rarely synthesized in mammals. Mutations in the POMGNT1 gene cause muscle-eye-brain disease (MEB), an autosomal recessive disorder characterized by congenital muscular dystrophy, ocular abnormalities, and lissencephaly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.