Thermo Fisher Scientific TNFRSF14 Monoclonal Antibody (5B5)
인간 TNFRSF14 단백질을 표적하는 Mouse IgG1 단클론 항체. Western blot 및 ELISA에 적합. Affinity chromatography로 정제된 액상 형태. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5B5 |
| Immunogen | TNFRSF14 (AAH02794.1, 38 a.a. approximately 200 a.a) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ALPSCKEDEY PVGSECCPKC SPGYRVKEAC GELTGTVCEP CPPGTYIAHL NGLSKCLQCQ MCDPAMGLRA SRNCSRTENA VCGCSPGHFC IVQDGDHCAA CRAYATSSPG QRVQKGGTES QDTLCQNCPP GTFSPNGTLE ECQHQTKCSW LVTKAGAGTS SSH
Target Information
TNFRSF14 is a member of the TNF-receptor superfamily and acts as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV envelope glycoprotein D (gD) to TNFRSF14 is part of the viral entry mechanism.
The cytoplasmic region binds several TRAF family members, mediating signal transduction pathways that activate immune responses. Activation in T cells stimulates proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity.
Multiple alternatively spliced transcript variants have been described, though some full-length variants remain undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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