Thermo Fisher Scientific TNFRSF14 Monoclonal Antibody (8A7)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
ALPSCKEDEY PVGSECCPKC SPGYRVKEAC GELTGTVCEP CPPGTYIAHL NGLSKCLQCQ MCDPAMGLRA SRNCSRTENA VCGCSPGHFC IVQDGDHCAA CRAYATSSPG QRVQKGGTES QDTLCQNCPP GTFSPNGTLE ECQHQTKCSW LVTKAGAGTS SSH

Target Information

TNFRSF14 is a member of the TNF-receptor superfamily. TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism. The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.

Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity. This suggests that TNFRSF14 may be a useful target for controlling cellular immune responses. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.